December 17 and 18, 2021, 10:00 AM - 5:00 PM (IST) on Virtual Platform
You tube live streaming link
Day-1:
https://youtu.be/Zz7xPARoWTE
Day-2:
https://youtu.be/BwZpE2CMJrw
Day 1: December 17, 2021
Session 1
10:00 AM - 1:00 PM
Next-Gen Sequencing based approaches have become a mainstay in diagnosing rare diseases. The basic three-step workflow consisting of sequencing, variant detection, and variant prioritization is well-established in clinical genomics laboratories, especially since it maps to different departments, each with its own skillset. The reducing cost of sequencing has encouraged laboratories to adopt larger panels in an attempt to improve the diagnostic yield. The number of genes sequenced for a condition has increased from the 10s to hundreds and thousands. Clinical exome panels with 5-7k genes and whole exome panels are increasingly used as the backbone for rare disease diagnosis. The larger data volumes that arise from these panels place additional demands on the variant detection and prioritization steps of the laboratory workflow. The variant detection step needs to guarantee a high accuracy (sensitivity and recall) to point mutations and copy number events occurring anywhere in the large panel. The variant prioritization step needs to allow scientists to quickly narrow down on the 1 or 2 variants that are clinically significant from the 10-50 thousand variants that are detected across these larger panels. AI-based approaches that aid these aspects of the workflow will be discussed in the talk. We will also discuss opportunities in knowledge curation and systematic knowledge generation that can aid rare disease diagnosis. Dr. Vamsi Veeramachaneni received his Ph.D. in Computer Science in 2002 from Penn State University for his work on algorithms related to genome sequence assembly. After a two year stint as a research associate in the Computational Evolutionary Genomics group, he joined Strand Life Sciences in 2004.
His early work at Strand was on NLP-based text-mining approaches for knowledge discovery from biomedical literature. His group worked on knowledge retrieval and visualization interfaces that would allow researchers to construct new pathways from millions of extracted relationships. Later, he oversaw the development of Strand's NGS analysis software for several years with a special focus on novel algorithm development and data visualizations that would allow researchers to verify the quality of the results derived from high-throughput sequencing analysis. He has been involved in Strand's foray into clinical diagnostics and has guided the development of analysis and interpretation workflows necessary for clinical-grade reporting.
As you may know, close to 2 lakh breast cancer patients are diagnosed every year in India, and it is also the biggest cause of cancer-related deaths in women. Today about 95% of breast cancer patients are treated with chemotherapy, but a vast majority (~70%) of the early stage (Stage 1,2) breast cancer patients do not benefit from chemotherapy. The side effects of chemotherapy are very painful for the patient and bring down the quality of life tremendously besides being a monetary drain. This devastating fact motivated us to develop our AI-based flagship product, "CanAssist Breast," which helps clinicians understand which patient might benefit from chemotherapy versus not. In turn, this allows clinicians plan a personalized treatment with patients with or without chemotherapy.
OncoStem Diagnostics is a med-tech start-up based out of Bangalore. Our constant endeavor to spread the message about breast cancer awareness. In this 45 min talk, I will discuss the technical details of CanAssist Breast and showcase how it is being used in real life to save patients from non-beneficial chemotherapy.
Manjiri Bakre, a gold medalist from R. Ruia College, University of Mumbai for B.Sc (Microbiology), has M.Sc in Microbiology/Biochemistry from MS University of Baroda. She received Ph.D. in Cell Biology from the Indian Institute of Science, Bangalore, in 1998 Post Ph.D. she has worked in the USA at Mt Sinai School of Medicine, NY, and at Moores Cancer Center, University of California at San Diego, CA, on very diverse cellular signal transduction areas such as perception of bitter taste and cancer biology. In 2003, she moved to the Genome Institute of Singapore and worked on human embryonic stem cells and cancer stem cells. Manjiri moved back to India in 2007 and led a group in cancer drug discovery at Avesthagen, followed by multidisciplinary research on 'point-of-care' diagnostics at Philips Research in Bangalore and The Netherlands. In 2011 she founded OncoStem Diagnostics Pvt Ltd in Bangalore. OncoStem is focused on developing innovative tests for avoiding over treatment of patients with chemotherapy drugs resulting in improved quality of life and huge savings. "CanAssist Breast" -flagship product for breast cancer patients is being sold in India and internationally for the last five years. CanAssist Breast is ISO 13485 and CE-IVD marked and has been used on more than 1600 breast cancer patients and resulting in savings of Rs 22 Cr + till date. The company is funded by Sequoia Capital and Artiman Ventures. Dr. Manjiri is a recipient of multiple awards like Young Scientist award given by the International Union of Biochemists and Molecular Biologists (IUBMB, 2006); Best Entrepreneur award - Global Women in STEM start-up (2017), Entrepreneur of the Year award from Indian Achiever's Forum (2021). She has published in many peer-reviewed journals such as Nature Medicine, has patents, mentored students, and given talks in prestigious international conferences in the US, Canada, Australia, Spain, S Korea, etc. She has extensive experience in multiple areas of biology and technologies such as microfluidic assays, microarrays, etc. In addition, her work published from Singapore has been given the Best Paper Award- given to the top 1% papers published annually by the Journal of Biological Chemists. Dr. Manjiri has also volunteered with iSpirt in 2020 for studies and rapid test development for Covid-19. OncoStem has won key awards like NASSCOM-Best Innovation of the year, E.T. Healthworld health-tech innovator of the year in 2019-2020, and Aegis Graham Bell award (2021) given by Ministry of Electronics and Information Technology, Government of India; NITI Aayog, India.
AI is expected to help improve healthcare services in many different ways. One area that needs focus is that of primary care, the first port of call for most patients. However, for various reasons, doctors at the primary level are often unable to diagnose and treat a range of relatively common conditions. This results in many such conditions being missed or patients getting referred to tertiary centers. This, coupled with the overall shortage of professionals, especially in rural settings, leads to poor quality of care at primary care levels, huge load at tertiary and specialist hospitals, and economic and emotional burden on patients and their families.
A first priority would be an e-health infrastructure that enables the collection and management of longitudinal health data of patients across hospitals. This can be complemented by AI-enabled tools that help primary care doctors, especially at PHC's, to diagnose and manage a wider variety of conditions: as examples, diagnostic point-of-care equipment for better treatment, and clinical decision support systems for management of chronic conditions at local levels. At the other end of care, improved screening and diagnostic tools can help reduce the load on specialists. We also discuss research at the E-Health Research Center at IIIT-B both in the areas of health data management as well as applications of AI in patient interactions and medical image analysis.
Dr. T K Srikanth is a Professor in Computer Science at IIIT Bangalore. His research interests are in systems for the management and analysis of healthcare data, data privacy, geometric modeling, and computer graphics. He is a co-convenor of the E-Health Research Center at IIITB and is actively involved in multiple collaborative research projects in healthcare, with a focus on public health. Prior to joining IIITB, he had extensive experience in the software industry, in India and in the US, in mobile and multimedia technologies and geometric modeling. He has a Ph.D. in Computer Science from Cornell University and a B.Tech. in Mechanical Engineering from IIT Madras.
Day 1: December 17, 2021
Session 2
Our healthcare system is obsolete and broken. The pandemic only amplified the underlying cracks in our infrastructure. We have close to 2M hospital beds in India which are set to double by 2025; however, the healthcare professionals catering to those beds are not. Against a recommended 1:4 nurse to patient ratio, most parts of our country are at 1:40. We have over 55M cardiovascular patients but around 5000 cardiologists to cater to them. This divide is only increasing, and the only way to bridge it is through technology. It will take no less than a tech revolution in healthcare to achieve this, but how does one drive tech adoption in the industry where most of the care is delivered on paper and we still use machines that were designed two decades ago.
Gaurav Parchani - CoFounder & CTO Dozee. He loves solving math problems and creating technology that impacts. His dream is to create an intelligent engine that takes care of the nation's health and puts quality healthcare in reach of every individual. Gaurav hails from the first batch of IIT Indore and has been recognized in Forbes India 30 under 30 & Business World 40 under 40.
Medical care today is fragmented and inefficient. On one hand, you have disorganized paper-based, error-prone, clunky systems that do not have the patient's or the caregiver's best interest in mind. On the other hand, you have technology-based "perceived" solutions that seem to be the panacea for what ails health care. Unfortunately, these solutions are themselves poorly designed, cumbersome to use, and often make a bad problem worse. They do not help and they do not work.
In a typical health care setting, there are two actors - the patient (the recipient of care) and the care provider (doctors, nurses, and allied professionals). The event that unfolds is care.
Today's actors in the healthcare scene are disenfranchised. What is acutely needed is a framework for empowering them. The framework needs to have an enabler that is tuned to the needs of the two actors and is coupled to the actions that the actors perform.
Dileep Raman is the co-founder and Chief of Healthcare at Cloudphysician, a healthcare technology company that remotely provides ICU expertise to hospitals that do not have access to ICU specialist doctors. In his capacity as the Chief of Healthcare, Dileep is responsible for overseeing the clinical operations and product development of the company. Dileep and his co-founder have grown Cloudphysician to a 100 people organization. He has led large teams in remote healthcare delivery and has led the development of Cloudphysician's state-of-the-art ICU management platform, RADAR. Dileep trained in Pulmonary, Critical Care, and Sleep at the Cleveland Clinic Foundation, USA. He graduated medical school from the
Government Medical College Thrissur, India, with a distinguished gold medal in internal medicine for academic excellence. Following which he completed his residency in Internal Medicine at Texas Tech University, USA, where he served as Chief Medical Resident. Dileep has numerous teaching awards for resident and fellow education, including the Cleveland Clinic Foundation teaching excellence award.
The ongoing COVID19 Pandemic has highlighted the need for Automated Diagnosis of Chest X-rays. In this talk, we will discuss XraySetu, a Whatsapp-driven Automated tool for Diagnosing Lung Infections, which provides swift Decision support to Doctors in Diagnosing COVID19. The tool is developed by Niramai Health Analytix and IISc in collaboration with ArtPark. Anecdotal evidence suggests that the tool is most effective in Geographical regions there are an acute shortage of Radiologists.
Chiranjib Bhattacharyya is currently a Professor and the Chair of the Department of Computer Science and Automation, Indian Institute of Science. His research interests are in the foundations of Machine Learning, Optimisation, and their applications to industrial problems. He has authored numerous papers in leading journals and conferences in Machine Learning. Some of his results have won best paper awards. He joined the Department of CSA, IISc, in 2002 as an Assistant Professor. Prior to joining the Department, he was a postdoctoral fellow at UC Berkeley. He holds B.E. and M.E. degrees, both in Electrical Engineering, from Jadavpur University and the Indian Institute of Science, respectively, and completed his PhD from the Department of Computer Science and Automation, Indian Institute of Science. He is also a fellow of the Indian Academy of Engineering. For more information about his work, please see http://mllab.csa.iisc.ac.in.
Light-weight Convolutional Neural Networks (CNNs) are mobile-friendly models that can provide inference without the need for any specialized hardware. These models can be very effective in point-of-care settings, where the detection of disease has to be performed in real-time. The talk will highlight a few developments of the Medical Imaging Group (MIG) at the Indian Institute of Science, especially towards COVID19 management and diagnosis. Deployment of these lightweight networks on embedded platforms to show highly versatility as well as prove optimal performance in terms of being accurate will also be highlighted. The developed models having latency in the same order as other lightweight networks without compromising the accuracy will also be shown.
A first priority would be an e-health infrastructure that enables the collection and management of longitudinal health data of patients across hospitals. This can be complemented by AI-enabled tools that help primary care doctors, especially at PHC's, to diagnose and manage a wider variety of conditions: as examples, diagnostic point-of-care equipment for better treatment, and clinical decision support systems for management of chronic conditions at local levels. At the other end of care, improved screening and diagnostic tools can help reduce the load on specialists. We also discuss research at the E-Health Research Center at IIIT-B both in the areas of health data management as well as applications of AI in patient interactions and medical image analysis.
Phaneendra Yalavarthy received B.Sc. and M.Sc. degrees in physics from Sri Sathya Sai University, Puttaparthy, India, in 1999 and 2001 respectively. He also obtained an M.Sc. degree in Engineering from the Indian Institute of Science, Bangalore, India in 2004. He received a Ph.D., working as a US Department of Defense Breast Cancer Pre-doctoral Fellow, in biomedical computation from Dartmouth College, Hanover, USA, in 2007. He worked as a postdoctoral research associate in the Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, USA, from 2007-2008. Currently, he is working as a Professor in the Department of Computational and Data Sciences, Indian Institute of Science, Bangalore, India.
His research interests include Computational methods in medical imaging, deep learning in medical imaging, medical image processing (reconstruction/analysis), physiological signal processing, diffuse optical imaging, and photoacoustic imaging. He is a senior member of IEEE, OSA, & SPIE and serves as an associate editor of IEEE Transactions on Medical Imaging. More details can be found @ http://cds.iisc.ac.in/faculty/yalavarthy/
Day 2: December 18, 2021
Session 3
The term Digital Health implies different things to different groups of people. Typically, it is assumed to encompass all activities where computers or digital technologies are implemented - including managing operations, including diagnostics all of which are most often related to the delivery of "healthcare" to be differentiated from "health" itself. Advancing technology (especially semiconductor), new sensors, and access to computing capabilities (platforms and tools) at distributed locations (makerspaces), has resulted in a disruption of established players. While this changed paradigm of technology - both in terms of research to drive change and funding becoming "externalized" to stakeholders often outside the medical domain has created new opportunities, it also resulted in new challenges.
We will try to address some of these issues related to data management and sharing, privacy, confidentiality, regulatory framework, fear of loss of focus on clinical interactions and the human touch, the need for a new ontology, assessing technology, managing costs and the ability of the medical fraternity to assimilate and assess emerging technologies.
Dr. Joy Mammen completed his undergraduate (MBBS) and post-graduate training (M.D. Pathology) in CMC Vellore, followed by a Fellowship in Pathology Informatics in the USA. He has worked at CMC since 1999, currently heading the Department of Transfusion Medicine, and is Associate Director at CMC.
His areas of interest include lab haematology, automation, proficiency testing information management, policy, and public health aspects of Blood Transfusion Service. He consults in these domains for National Health Mission, State & National Blood Transfusion services & WHO (SEARO). He also serves on the board of ICCBBA an organization responsible for International Standards Blood transfusion and Transplant. To know more about his work, see https://scholar.google.com/citations?user=pZ-dKmoAAAAJ&hl=en
Will be updated soon
Will be updated soon
A prime challenge in building data-driven inference models is the unavailability of a statistically significant amount of labeled data. Datasets are typically designed for a specific purpose and accordingly are weakly labeled for only a single class of tasks instead of being exhaustively annotated. Despite there being multiple datasets that cumulatively represent a large corpus, their weak labeling poses a challenge for direct use in knowledge integration. In the case of retinal images, specific datasets exist for the development of data-driven machine learning-based algorithms for segmenting anatomical landmarks like vessels and optic disc as well as pathologies like microaneurysms, hemorrhages, hard exudates, and soft exudates. The aspiration is to learn to semantically segment all such classes using only a single fully convolutional neural network (FCN), while the challenge being that there is no single training dataset with all classes annotated. We solve this problem by training a single network using separate weakly labeled datasets.
Essentially we use multi-task and adversarial learning approaches in addition to the classically employed objective of distortion loss minimization for semantic segmentation using FCN. This talk would focus on a general introduction to learning theory, the objectives of performance optimization in deep neural networks through learning, and the art of crafting new learning rules in view of solving such classes of critical problems. This talk would also introduce the "Turing Test Loss" which has been the driver in solving such optimization problems which require perception loss minimization rather than the classical distortion loss minimization. This approach has also helped in developing a just-in-time intervention for COVID-19 CT-based diagnosis while integrating knowledge from multiple partially labeled datasets. Advancing beyond this, a specific use to neuro-imaging would be discussed, whereby employing these basic concepts, we have been able to generate missing MRI sequences in neuro-imaging. This allows us to engage in obtaining missing data sequences when it is not possible to obtain all sequences in MRI imaging. Dr. Debdoot Sheet is an Assistant Professor of Electrical Engineering with a joint appointment at the Centre of Excellence in Artificial Intelligence at the Indian Institute of Technology Kharagpur and founder of SkinCurate Research. He also serves as the Joint Project Director of the IIT Kharagpur AI4ICPS I Hub Foundation and is the Local Organizing Chair for the IEEE International Symposium on Biomedical Imaging (ISBI) 2022 Kolkata, India. He received the BTech degree in electronics and communication engineering in 2008 from the West Bengal University of Technology, Kolkata, MS, and Ph.D. degrees from the Indian Institute of Technology Kharagpur in 2010 and 2014, respectively. His current research interests include deep learning, high-density multi-linear algebra tensor computation, computational medical imaging, image and multidimensional signal processing, and the social implications of technology. He has been a Chartered Engineer since 2021, DAAD alumni and was a visiting scholar at the Technical University of Munich during 2011-12, recipient of the IEEE Computer Society Richard E. Merwin Student Scholarship in 2012, the Fraunhofer Applications Award at the Indo-German Grand Science Slam in 2012, winner of the GE Edison Challenge 2013, Distinguished Alumni of IEM Kolkata 2016, Senior Member of IEEE class of 2019, member of MICCAI, Life member of IE (India), BMESI, IUPRAI, and serves as Regional Editor of IEEE Pulse.
Day 2: December 18, 2021
Session 4
The COVID-19 pandemic turned a few of us into accidental epidemiologists. In this talk, I will speak about our journey on the R&D of data-driven decision frameworks for COVID-19 response. I will cover three aspects - simulation models, our interactions with policymakers, and efforts in data sharing.
I will touch upon the city-scale agent-based simulator, its use in modeling the impact of the Mumbai locals, the Campus Rakshak (campus-scale) simulator, the workplace readiness self-assessment tool, the swabs2labs tool for efficient use of lab capacity, the Karnataka serosurveys, their use in forecasting and assessing the heterogeneity of COVID-19 spread across the districts, our struggle with variant modelling, the Rt calculator for India states and the districts of Karnataka, the early warning system, our recent collaborative effort to keep alive the efforts of the covid19india.org volunteers, and the forecast hub -- or how we learnt to stop pushing our model and embrace half-a-dozen. We hope a few of these tools will survive to help us in the future.
Rajesh Sundaresan received the BTech Degree in Electronics and Communication from the Indian Institute of Technology Madras and the M.A. and Ph.D. degrees in Electrical Engineering from Princeton University. He then worked at Qualcomm Inc. on the design and development of wireless modems. He joined IISc in 2005, where he is a Professor in the Department of Electrical Communication Engineering and an associate faculty in the Robert Bosch Centre for Cyber-Physical Systems. He has held visiting positions at Qualcomm Inc., the Coordinated Sciences Laboratory of the University of Illinois at Urbana-Champaign, the Toulouse Mathematical Institute, Strand Life Sciences, and the Indian Statistical Institute's Bengaluru Centre. His research interests include decision theory, communication, computation, and control over networks, cyber-social systems, and, more recently, data-driven decision frameworks for public health responses.
To combat the rising burden of non-communicable diseases (NCDs) in India, the Ministry of Health and Family Welfare launched the Population-Based Screening and Management of NCDs program under Ayushman Bharat Health and Wellness Centers in 2018. Dell Technologies and Tata Trusts have been partnering with the Ministry since 2017 to develop the technology system for the PBS NCD initiative. It consists of a suite of mobile and web apps on a cloud platform for health workers, doctors, and health administrators and has been deployed in states across the country.
One of the innovations piloted under the program has been an integration with a Clinical Decision Support System developed by AIIMS for medical officers at the public health facilities for hypertension and diabetes. It ran as an implementation science study in Punjab in collaboration with AIIMS & CCDC and has successfully demonstrated the concept of task shifting and the adoption of technology in a busy public health setting.
Sunita Nadhamuni is Head of Digital LifeCare at Dell Technologies, leading an innovation group for the digital transformation of public healthcare services working with the Govt of India for the Ayushman Bharat health program. This is a social impact, CSR initiative of Dell. Sunita has a unique combination of more than a decade of IT experience from the Silicon Valley in the US and a decade in India leading social impact initiatives. She was the CEO and is now Chairperson of Arghyam, a leading charitable foundation working towards water security in India. Sunita has an MS from Rensselaer Polytechnic Institute in NY, and a BE from Andhra University, was a TED India Fellow and on several non-profit boards.
Vamsi Veeramachaneni
Advances in rare disease diagnosis
Abstract
Manjiri Bakre
Does every breast cancer patient need chemotherapy?: Role of AI in decision making
Abstract
T. K. Srikanth
Can AI help improve primary healthcare services?
Abstract
Gaurav Parchani
AI for accessible and inclusive healthcare
Abstract
Dileep Raman
Welcome to AHI, not quite AI
Abstract
Chiranjib Bhattacharya
XraySetu: Bridging Access to Healthcare during COVID19 Pandemic
Abstract
Phaneendra Yalavarthy
Mobile Friendly Deep Learning Algorithms for Medical Image Analysis
Abstract
Joy Mammen
Challenges to Digital Transformation of Health
Abstract
Tavpritesh Sethi
Artificial Intelligence for Critical Care and COVID-19
Abstract
Debdoot Sheet
Adversarial Learning for Knowledge Integration from Weakly Labelled Datasets
Abstract
Rajesh Sundareshan
Data-driven decision frameworks for COVID-19 response - A personal journey
Abstract
Sunita Nadhamuni
Digital Transformation in Public Health - the National NCD IT system
Abstract
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